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Here, we have a equation and we need to find which of the following options will give the correct answer.
BODMAS Rule is:

Given : 16 * 4 * 8 * 10 * 2 * 16
So, we will substitute all the options one by one as shown below:
1) ×, ÷,–,+, =
⇒ 16 * 4 * 8 * 10 * 2 * 16
Substituting 1st option, we will get,
⇒ 16 × 4 ÷ 8 - 10 + 2 = 16
Using the BODMAS rule, we will get,
⇒16 × 0.5 - 10 + 2 = 16
⇒ 8 - 10 + 2 = 16
⇒ 0 = 16, which is not possible. So, option 1 is not true.
2) –,÷,+,×, =
⇒ 16 * 4 * 8 * 10 * 2 * 16
Substituting 2nd option, we will get,
⇒ 16 - 4 ÷ 8 + 10 × 2 = 16
Using the BODMAS rule, we will get,
⇒ 16 - 0.5 + 10 × 2 = 16
⇒ 16 - 0.5 + 20 = 16
⇒ 35.5 = 16, which is not possible. So, option 2 is not true.
3) ÷,+,×,–, =
⇒ 16 * 4 * 8 * 10 * 2 * 16
Substituting 3rd option, we will get,
⇒ 16 ÷ 4 + 8 × 10 - 2 = 16
Using the BODMAS rule, we will get,
⇒ 4 + 80 - 2 = 16
⇒ 82 = 16, which is not possible. So, option 3 is not true.
4) ÷,–,+, ×, =
⇒ 16 * 4 * 8 * 10 * 2 * 16
Substituting 4th option, we will get,
⇒ 16 ÷ 4 - 8 + 10 × 2 = 16
Using the BODMAS rule, we will get,
⇒ 4 - 8 + 20 = 16
⇒ 16 = 16, which is not possible. So, option 4 is true.
Hence, the correct sign is '÷,–,+, ×, =' to get the correct equation